A blood pressure medication called isradipine has shown promise for preventing alcohol and drug addiction, the researchers said.
Now, a team that has successfully stopped cocaine and alcohol addiction in rats using a drug already approved for the
treatment high blood pressure suggests the compound – called isradipine – may prevent relapse deleting
unconscious triggers memories of underlying addiction.
The researchers, from the University of Texas at Austin, report their findings in the journal Molecular
Before the 1970s, many scientists believed that addiction was a physical desire that could be overcome with
Now, increasingly addiction regard as brain rewiring problem and relapse during recovery may be
encounters triggered by environmental cues that have become strongly associated with addiction
Russian physiologist Ivan Pavlov found that if a bell rings every time you feed a dog, eventually the sound of the bell on your own
– No food – will cause the dog to salivate
For the study, the team -. Led by Hitoshi Morikawa, associate professor of neurology professor – focused on the brain
known to be involved in learning circuits, memory and reward, which are intended to become Rewired in addiction,
forming powerful memories of drug-related signals.
rats to associate either a black or white room with cocaine or alcohol were trained since became addicted to
After the animals had become addicted, researchers offered the option to enter the black
or in the cleanroom. Rats almost always chose the room they associated with the addictive substance.
isradipine erases memories that associate a signal with the addictive substance
Then the researchers gave some of the addicted rats a high dose of isradipine just before the presentation
with a variety of rooms. On the day they were treated rats still prefer the room related to your substance
use. But in later days, they no longer showed a particular preference. This did not happen in untreated
“The isradipine erase the memories that led them to associate a certain room with cocaine or alcohol,” explains Professor Morikawa.
isradipine reduces blood pressure by blocking calcium channels in the heart and blood vessels. However, these calcium channels are also present in the brain, and researchers suggest locking the
isradipine may have had the effect of rewiring the circuitry underlying the memories associated signals addiction –
like the colors of the rooms of cocaine and alcohol in experiments with rats.
A drug that targets the triggers that lead to addiction is likely to be more effective than drugs
currently used to prevent people from experiencing the euphoria that accompanies the consumption of addictive drugs, says Professor
Morikawa. He explains:
“Addicts show up the rehabilitation center already addicted Many addicts want to quit, but their brains.
They are already conditioned. This medicine may help the addicted brain become addicted-to “.
isradipine is already approved by the Administration of Food and Drug (FDA) as safe for human use and should not be take as
time to complete clinical trials as a new drug, not approved.
However, as isradipine is designed to reduce blood pressure , it may be necessary to synchronize with another drug
stops low blood pressure. This could be a challenge to get the drug through trials as a treatment
Meanwhile, Medical News Today recently learned that illicit drug use
in the workplace appears to be increasing in the US .. The data of millions of urine tests suggest workplace
proportion of US workers tested positive for illicit drugs – like marijuana, cocaine and methamphetamine –
is about 5%, on a second annual increase.