Researchers at Pennsylvania State University have discovered potential to guide the development of future methods a new look treatment of Alzheimer’s disease.
Professor Gong Chen and his team found that there was a very high level of a neurotransmitter in the brain dead patients who had this type of cognitive impairment.
This neurotransmitter called gamma-aminobutyric acid (GABA), was in a part of the brain called the dentate gyrus, which is the entrance to the hippocampus. This is a crucial part of the brain that is responsible for learning and memory.
Those with Alzheimer’s disease had significantly increased levels of GABA in the cells that surround and support each neuron in the brain of healthy individuals without the degenerative disorder.
Professor Chen said the findings of this study “can be oriented in further research as a tool for the diagnosis and treatment of Alzheimer’s disease.”
The team also established new methods for determining the concentration of GABA in mouse models with and without the condition. It was learned that animals with high levels of the neurotransmitter also perform poorly on tests of learning and memory.
This discovery comes in the light of the disappointing results of drugs for this form of dementia, which actually shown to have a negative effect on people with the disease, rather than improve it.
It was this failure that provides motivation for teacher Chen and his team to try to devise a way to fight the disease that wreaks havoc on the brain’s memory capacity.
The purpose of these methods ineffective treatment had targeted in the accumulation of amyloid protein, which is widely regarded as a hallmark of the disease.
Professor Chen said. “The research of our laboratory and others now has focused on the search for new drug targets and the development of new approaches to diagnosis and treatment of Alzheimer’s disease”
No cure has been found for this degenerative disease and is believed to affect 800,000 people in the UK alone. For the year 2021, more than one million people have the condition.
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Posted in: Alzheimer's & Dementia