Animal studies show that the combination of progesterone and estrogen naturally bioidientical provides a secure way of HRT. Here Dr. Dach focuses on why progestins are not the answer and can increase the risk of breast cancer.
studies hormone Primate Center in Winston Salem are very revealing and allow us to answer questions about the different effects of various hormonal formulations.
often cite the French cohort of 2008 Study by Fournier demonstrate the safety of bioidentical hormones. This study showed that users in France bioidentical hormone (estradiol and progesterone) had the same breast cancer risk as users nonhormonal. In other words, there was no increased risk of breast cancer with this combination of bioidentical hormones.
Adding medroxyprogesterone (MPA)
When the progestin is added medroxyprogesterone (MPA), there is an increased risk of breast cancer. However, there is no increased risk with the addition of progesterone. Confirmatory findings were seen in WHI (first arm) , which also showed increased invasive breast cancer with the combination of Premarin and Prempro also called medroxyprogesterone study.
Now that we have the tracking data 11 years of second arm, Premarin-Alone (EEC horse estrogen) Initiative study of Women’s Health, we can ask some questions plus. Premarin-Alone arm 20-27% showed in breast cancer decrease compared to placebo.
Why cancer with less Premarin-Alone, and more with estradiol alone?
One could ask the obvious question: “Why is associated with a decreased risk of breast cancer compared with nonhormonal users Premarin-Alone, while estradiol-alone (bioidentical ) is associated with an increase of 29% in invasive breast cancer in the French cohort study?
the answer comes from Dr. wood in the primate center in Winston Salem, in a 2008 report using macaques. They compared Premarin and estradiol in a monkey model, and found to 259-330% increase in significant cell proliferation in monkeys treated breast estradiol compared to controls. monkeys treated Premarin however, were much less cell proliferation, only 75% was observed by antigen testing KI-67 cell proliferation.
This difference in cell proliferation, indicating an estrogenic effect stonger estradiol, estradiol alone explains why is associated with increased risk of breast cancer, while not Premarin. Premarin has less proliferative effect on breast tissue makes Estradiol as demonstrated in monkeys, and different rates of breast cancer in human studies.
Why is it important to Add progesterone
So this highlights the importance of the addition of progesterone to estradiol regimen alone. Postmenopausal women received estrogen alone regimen due to prior hysterectomy may be at increased risk of breast cancer and would be better than any of progesterone add to your program, or switch to a combination / bioidentical estrogen progesterone. preferably combined to ensure that both hormones are taken together in the appropriate ratio to prevent endometrial hyperplasia and reduce the proliferation of breast cream is used. We also ensure all user hormones take iodine supplements, which are breast cancer preventive.
protective effects of progesterone compared to the harmful effects of medroxyprogesterone – Mobile breast proliferation
Another question we might ask is:
“How can we explain why medroxyprogesterone causes increased breast cancer, while (bioidentical) progesterone no”
Dr. Wood published one hormone primates study in 2007 in which medroxyprogesterone (MPA) was compared with progesterone, estradiol plus medroxyprogesterone search (MPA) significantly increased cell proliferation markers Ki67 breast using. However, progesterone estradiol did not increase cell proliferation. Previous studies in primates by Cline in 1998 showed the same breast cell proliferation increases with the addition of medroxyprogesterone Premarin-treated monkeys.
Dr. Cline conclusion:
“These results indicate that progestins can exacerbate , no antagonize proliferation of mammary gland induced by estrogen (Premarin) replacement therapy “
This protective effect of progesterone (bioidentical) was confirmed in two double human-blind studies Chang and Foidart in that the addition of progesterone reduces the proliferative effects of estrogen, which explains its cancer preventive effect. (19,20) the proliferation of breast cancer is the underlying factor in the increased risk of cancer. Inhibition of proliferation of breast prevents breast cancer.
Armed with this information about estriol, we can now say with confidence that the combination with progesterone is the safest HRT regimen one can possibly conceive.
The reader is reportedly to discuss the comments on these pages with his / her personal medical and act only on the advice of his / her personal physician. More information about Jeffrey Dach and his work on his website: http://jeffreydach.com/
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