Our belly errors can produce useful or harmful metabolites to modulate cancer

Apr 25, 2016 | | Say something

Our belly errors can produce useful or harmful metabolites to modulate cancer ;

Dr. Sarah LoBisco, ND

If you has been paying attention to natural health lately, you probably have not escaped the explosion of research on the microbiome and its role in health. These small creatures that line our resident inside and take our bladders affect everything from our mood to cancer risk. However, the predominant populations, diversity and type (genus and species) of these little friends of ours is important if they are to produce overall benefit or affect our body.

Recently, a rodent study compared what would happen when mice bred to have mutations in the ATM gene mutation were occupied with (less pathogenic) bacteria or “restricted” “conventional”. (This mutation ATM is linked to a neurological disorder called ataxia telangiectasia and is associated with an increased risk of leukemia, lymphomas and other cancers). According to the authors of this study published in PLoS ONE, “Different strains of mice used in this study were defined as follows: ATM (knockout mice Atm carry restricted microbiota) -KO-RM; Atm -KO-CM (ATM carrying knockout mice conventional microbiota); WT-RM (wildtype mice carrying restricted microbiota) and WT-CM (wildtype mice carrying conventional microbiota) ” .

Previously the authors had shown that the onset of lymphomas in mice could be delayed until 7-12 months related to changes in intestinal microbiota, specifically with an increase in Lactobacillus johnsonii and reduction the incidence of lymphoma by administration of the antioxidant N-acetylcysteine.

The authors then analyzed fecal and urinary metabolite to assess differences in the results of rodent cancer based on the insect population that inhabited. Interestingly, the researchers found that the mice had restricted that were associated with the modulation of inflammation and cancer results more beneficial metabolites. For Biochem geeks out there, here’s a cool extract a result in fecal analysis:

The Atm -kō and WT-RM mice showed statistically significant regulation a number of metabolites including homophenylalanine, sphinganine, methyluridine and riboflavin sodium phosphate. There was a rise in the levels of kynurenic acid (a tryptophan metabolite) [ 53 ]. mice RM also showed elevation in fecal levels phosphate riboflavin (vitamin B2), which is a precursor flavin adenine dinucleotide (FAD) and flavin mononucleotide adenine (FMN) which are essential cofactors of TCA cycle. in addition, Atm -KO mice-RM showed changes in the relative abundance of free fatty acids, secondary bile acids and tripeptides, compared to Atm mice -KO-CM (Table 6). mice WT-RM showed differences in levels glycerophospholipids a series of di- and tripeptides and fatty acids. ”

The authors summarized the protective effects of beneficial metabolites as follows:

“Using an approach mass spectrometry high resolution, then asked how this translates in metabolic changes in mice that are genetically identical, but differ only in their gut microbiome composition. Surprisingly, we have found differently in the profiles of abundant metabolites of blood (data not shown). in addition, our analysis results urine and fecal suggest that intestinal microbiota different cause a metabolic shift to upregulation of metabolites including kyneurenic acid, methyladenine and 3-methybutyrolactone that can mitigate promotion signaling pathways cancer, reported that is associated with onco -Protector independent phenotype the genotype of the mice. we found that the restriction of the intestinal microbiota in Atm-deficient mice led to an extension of 2.5 times the latency of lymphoma and 4-fold increased longevity, and differences significant in chromosomal genotoxicity, oxidative DNA damage and inflammation … “

This is not the first study to show decreased tumor formation in the” germ-free rodents. ” Several studies have also shown a decrease in the incidence of cancer in rodents given antibiotics and rid of harmful bacteria. Furthermore, many are familiar with the clinical correlation between the pathogen H. pylori and gastric cancer.

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Increasingly, it becomes clear that the way modular environment in our gut (through diet, lifestyle, avoidance of toxins and unnecessary drugs, exercise, supplements, probiotics, and modulation of stress) can decrease or increase our risk of cancer and chronic diseases. (I check some of these tests in a future post.) In other words, these bugs within us affect our biochemists to modulate gene expression of a profoundly powerful way processes. The current study provides further evidence rodents in vivo than us, and our four-legged friends, may actually only be the result of what they eat our microbes!

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LoBisco041lowres Sarah Lobisco, ND , is a graduate of the University of the University of Bridgeport naturopathic medicine (UBCNM). She is licensed in Vermont as a naturopath and has a degree in psychology from the State University of New York at Geneseo. Dr. LoBisco is a comprehensive health speaker, has several publications, and is a candidate for certification in functional medicine. Dr. LoBisco now incorporates her training as a naturopathic doctor and practitioner of functional medicine through writing, research, private practice, and through independent contract work for companies regarding supplements, nutraceuticals, essential oils and food medical. Dr. LoBisco also enjoys continuing to educate and train their readers through their blogs and social media. His recent blog can be found at www.dr-lobisco.com .


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The Our Mistakes belly can produce useful or harmful metabolites to modulate cancer first appeared in NaturalPath .

This article was originally published on thenatpath, Read the original article here

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