A study shows that the drug can undo the genetic changes that cause Alzheimer

May 4, 2016 | | Say something

alzheimer's treatment

a drug that is already being used for treatment a neurological disorder is able to reverse the genetic changes associated with the key Alzheimer disease, says a study. The aging takes its toll on the brain and hippocampal cells – a region of the brain crucial for learning and memory circuits – are particularly vulnerable to changes that can lead to Alzheimer’s disease or cognitive impairment. Hoping to counter the changes that can lead to these two conditions, the researchers examined the effects of a drug called riluzole known to affect this circuit. ‘In aging and Alzheimer’s disease, chemical signal glutamate may accumulate between neurons, damaging the circuits, “said lead researcher Ana Pereira, of Rockefeller University in New York, United States (Read:. scientists reverse successfully symptoms of Alzheimer’s and Parkinson )

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‘When treated with riluzole, rats have seen a number of changes. Perhaps most importantly, the expression of molecules responsible for clearing excess glutamate returned to more youthful levels, “Pereira said. The drug riluzole is already being used for the treatment of amyotrophic lateral sclerosis the – a neurological disease that affects nerve cells in the brain and spinal cord – and therefore considered safe. The drug is modifying the activity of certain genes in an animal aged to resemble that of a young rat. For example, researchers found that the expression of a gene called EAAT2, which has been linked to Alzheimer’s disease and is known to play a role in removing excess glutamate from nerve fibers, decreases as age animals. (Read: 6 Tips to prevent the onset of Alzheimer’s disease )

However, in rats treated with riluzole activity of this gene was returned to its levels of youth. The research is described in the journal Molecular Psychiatry. Pereira’s previous work had shown that the drug caused structural changes in the neurons of rats that prevent memory loss often seen in old animals. Pereira is currently testing Riluzole for the first time in Alzheimer’s patients in a clinical trial at the Rockefeller University Hospital, said an official statement. “I hope to use a drug to break the cycle of glutamate toxicity by which can damage neurons that use it as a neurotransmitter, and our studies so far suggest that riluzole may be able to accomplish this, Pereira said. Here’s the detailed explanation of 10 the first symptoms of Alzheimer’s disease

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. Source: IANS

photo source: Getty images (image for only purpsoe representational)

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Posted in: Alzheimer's, Alzheimer's treatment, Brain disorder, brain health, Diseases & Conditions

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