Researchers have developed a new approach to override the defense mechanism cancer ovary cells, making it easier to remove permanently. Researchers at Oregon State University photodynamic therapy is used to fight ovarian cancer in laboratory animals using a combination of techniques that achieved complete elimination of cancer cells without re-growth of tumors. ‘ Cancer cells are very smart. They expressed about certain proteins, including one called DJ1, which help them survive an attack of reactive oxygen species that might otherwise kill them, “said study author Oleh Taratula.” We believe that the key to the success of this therapy is that these defense mechanisms is removed, “said Taratula (Read: the latest research and advances in cancer treatment ).
ovarian cancer has a high mortality rate, as it often has metastasized to the abdominal cavity before it is discovered. surgery and chemotherapy are traditional approaches to ovarian cancer , but it is very difficult to identify all sites in which a tumor has spread. ‘photodynamic therapy is a different approach that can be used as an adjunct to surgery right during operation, and appears to be very safe and nontoxic, Taratula said. in the new approach , a patient is first administered a photosensitizing compound called phthalocyanine, which produces reactive oxygen that kills cells when exposed to near infrared light. (Read: An error that is increasing the risk of cancer in women )
Moreover, gene therapy is administered lowering cellular defense against reactive oxygen species. The use of photodynamic therapy alone, some tumors in laboratory animals began to grow again after two weeks. However, with the addition of gene therapy to weaken combinatorial cellular defenses of cancer, there was no evidence of cancer recurrence. ‘Tumors exposed to a single dose of combination therapy were completely eradicated mice,’ Taratula concluded. During the proceedings, the mice that received gene therapy also continued to grow and gain weight, indicating a lack of side effects. (Read: 6 common tests to determine their cancer risk )
The findings were published in the journal, Nanomedicine :. Nanotechnology, biology and medicine
This article was originally published on thehealthsite, Read the original article here