Latest Cancer Research: Snail venom can keep those cures for cancer, nicotine addiction

Jun 1, 2017 | | Say something

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Washington, Jan 15: snail venom Cone can lead to medical treatments for some types of cancer and nicotine addiction, a new study has found. Cone snails are marine mollusks like snails, octopus and squid, but they capture their prey using poison. The venom of these sea creatures provides clues for detection and possible treatment of some cancers and addiction, the researchers said. Mari Frank, a professor in the Department of Chemistry and Biochemistry of Charles E Schmidt Faculty of Florida Atlantic University, has focused his research on snail venom.

“The poison produced by these animals immobilizes prey, which can be worms, snails and other fish. The venom is a complex mixture of compounds with medicinal properties extraordinary, “Mari said. The venom components selectively target cells in the body and make valuable drugs cables and powerful molecular tools for understanding the processes of the human body, the researchers said. One class of venom components is alpha-conotoxins, so called because they target the nicotinic receptors that are critical for a number of diseases, including Alzheimer’s disease, schizophrenia, addiction to snuff and lung cancer. (Read: molecules of biological clock routing cells have potential for the treatment of cancer )

The venom of a particular species of cone snail, regio Conus collected by the group of Mari, it is particularly rich in alpha conotoxins. Aldo Franco, who worked in the laboratory of Mari described ten new alpha-conotoxins in his doctoral thesis at FAU. Among these, the team found RegIIA, a compound that potently blocks the alpha3beta4 nicotinic receptor. This receiver particularly when activated may be associated with lung cancer and nicotine addiction. (Read: Latest Cancer Research: treatment personalized cancer soon )

“We have investigated in detail how RegIIA interacts with the alpha3beta4 nicotinic receptors and embarked on the engineering of new compounds that were more specific to the alpha3beta4 receptor and no other nicotinic receptors, “Mari said. ‘ Our goal is to open new avenues for cancer and addiction research inspired by compounds of marine animals, “said Mari. The research is published in the Journal of Biological Chemistry . (Read: Latest cancer research: drugs for bone loss can help prevent cancer )

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Source: PTI

Photo source: Getty images




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