New research offers hope for patients and difficult to treat breast cancer

Jun 13, 2016 | | Say something

New research offers hope for patients and difficult to treat breast cancer ;

micrograph of a lymph node invaded by ductal breast carcinoma with tumor spread beyond the lymph nodes. Credit: Nephron / Wikipedia

UK scientists have discovered a new way to reduce the growth of the most aggressive form of breast cancer, according to a study published in the journal Oncogene nowadays.

The team from the University of Oxford and the University of Nottingham found that the use of a drug called JQ1 can alter the form cancer cells respond to hypoxia or low oxygen which it is more than 50 percent of breast tumors general and more frequently in the triple negative breast cancer , the form of the disease that is more difficult to treat .

JQ1 works to stop cancer cells adapt to the oxygen deficiency. The study results showed that JQ1 slowed tumor growth and limits the number of blood vessels that were produced.

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When a breast cancer patient is deprived of oxygen that can be much more difficult to treat successfully. This is due to the way the cancer cells are adapted to low oxygen levels changes its biology and makes them resistant to standard therapies . When there are low oxygen levels, tumor cells activate specific genes that send signals of new blood vessels to supply them with fresh oxygen, giving cancer nutrients it needs to grow and spread.Dr Alan McIntyre, co-author of the study, at the University of Nottingham, said: “.. the triple negative breast cancer is a challenge to address hypoxia so often endangers the treatment of breast cancers, JQ1 could be an important key to helping women with aggressive breast tumors “

The study explains how the family of medicines to which belongs JQ1 works. Although this group of drugs called bromodomain inhibitors and extraterminal or Beti-has been used to treat cancer earlier, this study sheds light on the role that these drugs could play in hypoxia, which could prove vital for patients to treat cancers-breast difficult.

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Nell Barrie, manager of scientific communications of high level of Cancer Research UK, said: “This study has discovered ideas about how you could use these medications to help treat triple negative patients with breast cancer for those who urgently need better treatments. interfere with the body’s natural response to hypoxia, or low oxygen, it could be a way to stop the spread of cancer. Further studies should be conducted to measure how effective JQ1 could be in patients. “

Dr. Richard Berks, research communications officer in breast cancer now also supported the study, said: “The ability of breast cancers to adapt to the lack of oxygen is one of key features that helps them become resistant to standard therapies. Finding a way to thwart this process, therefore, could be an important tool for the development of new treatments pathway.

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“This study adds to the evidence that suggests that a class of drugs known as inhibitors of BET, which are already in clinical trials for other cancers, might be effective for treating cancers of aggressive breast.

“We desperately need to find more effective for these particularly aggressive forms of breast cancer, such as triple negative treatment, and if this finding is confirmed it could represent a real step forward.”

This article was originally published on medicalxpress, Read the original article

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