Researchers have found that knowledge of the first changes in the cells of the fallopian tubes of women who carry the genetic mutation responsible for ovarian cancer could open the way for new preventive strategies.The study tried to understand why women with BRCA1 / 2 ovarian cancer mutations and what happens in cells where they trigger cancers originate develops. The results showed that approximately 60 percent of women carrying the BRCA1 or BRCA2 gene, a subcellular activity radically altered cells produced in tubes that are closer to the ovary. Read about Symptoms of ovarian cancer.
“These new results give us a step closer to understanding how ovarian cancers develop in BRCA mutation carriers of genes 1/2, opening new opportunities for cancer prevention ovary, “said Martin Widschwendter, a professor at University College London. These subcellular changes were similar to those observed in cells of specimens.The changes of ovarian cancer were not seen in women without BRCA mutations.In addition, researchers identified an enzyme (activation-induced cytosine deaminase, AID ) that seems to trigger this re-programming. ‘This is vital because currently the most effective prevention method is reduction surgery drastic risks, which deprives women of their hormones and their ability to give birth before menopause, “added Widschwendter. reading experts say ovarian cancer can not prevent women from having a baby
For the study, published in journal Nature Communications , the team examined the tissue of post-surgical reproductive fallopian 115 women, 56 with BRCA1 / 2 mutation and a control group of 59 without.They analyzed ‘epigenetic programs, the “software cells” which dictates how cells read instructions encoded in DNA. In addition, the two ends of the fallopian tubes (fimbrial, closest to the ovary and uterus, closest to the matrix) were compared from the same woman.’The next steps will investigate the merit of drugs that affect epigenetic reprogramming and to find biomarkers that allow safe monitoring of the effects of these drugs, ‘Widschwendter concluded.
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