Zero gravity can improve the response of cancer drugs

Jun 13, 2016 | | Say something

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weightlessness shed new light on the effects of zero gravity on genetic perturbations, Indian researchers have shown can improve the response of cancer drugs. On the other hand, scientists say, it could also induce cancers and liver and leukemia in humans. The findings could help authorities in designing new drugs to combat diseases related to micro gravity. Using an approach of systems biology – computational and mathematical modeling of complex biological systems – experts at the Institute of Nuclear Physics Saha (SINP) and the University of Presidency here studied the links between gene expression and human health conditions microgravity. (Read: A new cancer drug to treat colorectal cancer shows promising results )

“The objective was to understand how various molecular pathways are regulated in response to microgravity and how it alters the expression of genes. Through a new type of analysis (systems biology), we have found the genetic signature of liver cancer leukemia and ‘Sangram Bagh, Ramanujan Fellow, Associate Professor, Biophysics and Structural Genomics Division, SINP, told IANS. “In addition, we have shown cancer medications can respond better in zero gravity,” Bagh, also the lead author of the study. The findings have been published in scientific reports Nature in May and equipment includes Sayaka Mukhopadhyay, Rohini Saha, Anbarasi Palanisamy, Madhurima Ghosh, Anupriya Biswas, Saheli Roy, Arijit Sarkar Pal and Kathakali. The researchers analyzed more than 8,000 molecular pathways involved in genetic changes and data from multiple human cell experiments in a space station, during spaceflight and facilities that produce zero conditions similar to Earth’s gravity. (Read 😕 Can cancer drugs cause cancer )

“Our results suggest a set of specific hypotheses that can be tested directly on a simulator of microgravity based on land or in conditions of space flight and can help assess the risks and development of new medicines for health hazards induced by micro gravity, ‘Bagh said. advanced statistical methods, machine learning algorithms and databases were deployed to understand the complexities surrounding microgravity and how activation pathways are regulated alterations in the genes. Despite a large number of studies in fields such as genomics, proteomics and transcriptomics, a complete picture of what is actually happening inside the cell was deficient, Bagh said. “There are two types of hazards in space exploration.. Radiation and microgravity People knew about the dangers of radiation, but no detailed study on the effects of microgravity on cancer from a genetic point of view report (Read anticancer drugs can prevent diabetes )

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“Our study is the first to report the genetic signatures of liver and leukemia in microgravity, ‘Bagh said. Moreover, Bagh said the results show also that zero gravity can reduce inflammation, autoimmunity, diabetes and asthma. “What we want to emphasize is that India is at the forefront of space research, but a dedicated space program biology is still lacking and that should start soon,” he added.

Source: IANS

Photo source: Getty images (image for representation purposes only)


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