A study indicates that most antidepressants do not help children with mental health problems

Jun 9, 2016 | | Say something

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According to a recent study, most available antidepressants no help children and adolescents with serious mental health problems and some may be unsafe. The results indicate that of the 14 antidepressants, only fluoxetine was more effective in relieving the symptoms of depression than placebo, while taking venlafaxine was associated with an increased risk of getting involved in thoughts and suicide attempts compared to placebo and five other antidepressants. However, the true efficacy and risk of serious problems, such as suicidal thoughts and attempts damage remains unclear due to the small number and poor design of clinical trials evaluating these antidepressants, and selective reporting of test results published and reports of clinical studies, the authors warn. “It seems that the balance of risks and benefits of antidepressants for treatment of major depression to offer a clear advantage in children and adolescents, with probably only the exception of fluoxetine. We recommend that children and adolescents taking antidepressants should be closely monitored, regardless of the chosen antidepressant, especially at the beginning of treatment, “explains co-author Xie Peng, Medical University of Chongqing. (Read: study says that antidepressants work best with nutrient supplements )

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The lead author, Dr. Andrea Cipriani at the University of Oxford, said: “Without access to the individual-level data is difficult to obtain estimates of the precise effects and can not be completely sure about the accuracy of the information contained in published and unpublished trials. it has often been said that there needs to be a transformation of scientific culture existing one where the exchange of responsible data should be the norm. ‘Cipriani said that hundreds of thousands of people around the world have agreed to participate in trials with the aim of finding better treatments for disorders and, ultimately, help the progress of medical science. the patient privacy must be guaranteed by adequate and technological measures policies, but the delay in implementing responsible policies for data sharing has negative consequences for medical research and patient outcomes, as has demonstrated in this study. Access to the data of raw clinical trials provides the unique opportunity not only for validation and replication of results, but also the in-depth study of specific factors that may affect the outcome of treatment at the level of the individual patient (s say :. How do antidepressants work )

The analysis of 34 trials with 5260 participants (mean age of 9 to 18 years) showed that the benefits outweigh the risks in terms of efficacy and tolerability only for fluoxetine. Nortriptyline was less effective than seven antidepressants and placebo. Imipramine, venlafaxine, duloxetine and had the worst tolerability profile, resulting in a significantly higher number than placebo interruptions. Venlafaxine was linked to an increased risk of engaging in thoughts or suicide attempts compared to placebo and five other antidepressants. The authors caution that because of the lack of reliable data, it was not possible to comprehensively assess the risk of suicide for all medications. The study is published in The Lancet . (Read: natural antidepressant options should try )

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Source: IANS

Photo source: Getty images (image for only representation purposes)


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Posted in: Antidepressants, Children's health, Depression, Diseases & Conditions, Teenagers

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