deadly TB strains emerged in Asia over 6,000 years ago

Jan 20, 2015 | | Say something

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London, Jan 20: in a groundbreaking finding an evolutionary geneticist at the National Museum of Natural History in Paris has decoded the tuberculosis (TB) genome, suggesting that a pernicious family of strain emerged in Asia more than 6,000 years. The study of nearly 5,000 samples of Mycobacterium tuberculosis worldwide showed how a strain of bacteria that thousands of years ago emerged in China has become a widely resistant to antibiotics overall murderer, reported the journal Nature Genetics . The evolutionary geneticist Thierry Wirth and his team analyzed 4,987 samples of the ‘Beijing lineage “of 99 countries, the complete sequencing of the genomes of 110 of them and extends more limited DNA in the rest.

the researchers then used the information to date the expansion of lineage and show how the strains interact. In keeping with its name, the “Beijing lineage ‘did emerge near the northeast China.’ and did some 6,600 years ago which coincides with the archaeological evidence of early rice cultivation in the valley of the upper Yangtze river in China, “Wirth said. Although M. tuberculosis probably emerged first ago 40,000 years in Africa, the disease did not take hold until humans came to agriculture with consequent settling down (Read: 5 ways to prevent TB ).

‘The grouping of people in settlements made it easier for the respiratory pathogen to spread from one person to another,’ Wirth said. Of all strains of the bacterium M. circulating today, scariest few strikes in the public health officials that the lineage of Beijing. First identified in greater Beijing in the mid-1990s, this lineage now circulates throughout the world and many strains are resistant to drugs that beat other types of TB. The increasing availability of antibiotics in the 1960s, meanwhile, coincides with a drop in the number of bacteria. The line, however, recovered in late 1980 and early 1990. (See: World Tuberculosis Day 2014-10 reasons docs think that the burden of tuberculosis is increasing )

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Since its inception, the “Beijing lineage ‘has become much more infectious, Wirth says, so it was compete other strains of bacteria. their mutations team identified in relation to antibiotic resistance, metabolism and evasion . of the immune response that may have contributed to the success of the ‘lineage Beijing (Read: World tuberculosis Day 2014: 6 strategies to overcome challenges in the treatment of tuberculosis )

Source: IANS

photo source: Getty images


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