Japanese researchers have discovered metabolites that are specifically related to aging and shed light on how the human body ages. Metabolites, substances that are created during metabolism, can provide a lot of information about an individual’s health, disease, diet , and lifestyle. The study results identified some metabolites in the blood that increases or decreases in the older adults. The researchers found 14 age-related metabolites. Half of them decreased in elderly and half rose. Antioxidants and related decrease in muscle strength in the elderly, while metabolites related to decreased renal and hepatic function increased metabolites.
“Of the 14 compounds, half of them had decreased in the elderly. The decrease was found in antioxidants and compounds related to muscle strength. Therefore, the elderly have fewer antioxidants and less muscular strength, “said lead researcher Yanagida, a professor at Okinawa Institute of Science and Technology Graduate University (OIST) in Japan. In addition, some of the metabolites related with age found in the same metabolic pathways have connected the changes, suggesting that age affects them simultaneously (Read: will soon be able to prevent aging and stay young ).
‘related compounds functionally show the same trends to increase or decrease with age, or in other words, show similar correlations, “Yanagida said in the study published in the journal PNAS . The decrease in antioxidants and muscle strength is important to suggest that people who eat foods rich in antioxidants and continue the exercise, especially after the age of 65. This could help increase levels related metabolites in the body and improve conditions in the body, the researchers noted. (Read: started aging, even before birth )
“Longevity is a great mystery to us … We want to find how the elderly can live a happy end stage life. This is the way we can contribute to human health “, held Yanagida To find and analyze metabolites, the team obtained blood samples, including red blood cells (RBCs) from 30 healthy individuals. 15 young adults and 15 adults. Then, liquid chromatography-mass spectrometry (LC-MS), a technique that separates liquid and detects substances, for identifying metabolites in the blood. from there are used, they could be calculated coefficients variation, or standard deviation of the metabolite abundance divided by the average, to identify compounds that had increased or decreased in older adults. (Read: unhealthy diet and sedentary lifestyle can trigger aging )
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