Researchers have discovered a gene involved in the deregulation of certain immune cells in the neurological disease multiple sclerosis (MS) .Characterised by the appearance of chronic, neurodegenerative central nervous system damage, this, the disease often unpredictable disabling interrupts the flow of information in the brain and between the brain and body attacking the protective sheath (myelin) that covers nerve fibers. Reading Can vitamin D3 treat multiple sclerosis?
At this time, the cause is unknown although several auto-immune mechanisms involved to be known. Researchers are already aware of that genetic variants lead to changes in the component code DNA and, in order to understand their biological effects, the effects of expression of the corresponding need for genes to be studied, in other words, changes in messenger RNA and proteins. Reading Suffering from multiple sclerosis? Following a diet that resembles fasting
The new study showed that the gene known as ANKRD55 produces three different messenger RNA transcripts, and that the genetic variant associated with MS greatly increases the production of these transcripts. “We have also discovered and shown that this is done specifically in the case of a particular category of cells of the immune system cells called CD4 +, ‘said lead author of the research Koen Vandenbroeck Ikerbasque, the Basque Foundation for Science in Spain.
‘This suggests that ANKRD55 has significant biological function in these cells and that now has to be deciphered, “he said. CD4 + T are of crucial importance in the generation of cellular immune responses and protection are believed to be deregulated in multiple sclerosis. This study concluded that the ANKRD55 gene may play a key role in this deregulation. The findings were published in Journal of Immunology.
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