weight loss by modifying the lifestyle and bariatric surgery can significantly reduce the characteristics of nonalcoholic steatohepatitis (NASH), a disease characterized by fat in the liver, according to studies. “While the underlying cause of NASH is unclear, is this condition more frequently in patients who are middle age and obesity,” said lead author Giulio Marchesini of the University of Bologna, Italy.
A weight loss of 10 percent or more is needed to carry out the resolution NASH and reverse scarring of the liver in patients with overweight and obesity. To a lesser extent, moderate weight loss (seven to 10 percent) reduced the severity of the disease in certain subgroups of patients, including male patients and those without diabetes . By contrast, 93 percent of patients with little or no reduction in weight (less than five percent) experienced worsening liver scarring, described the study reported in Gastroenterology.
In the second Gastroenterology, Guillaume Lassailly and colleagues from France report that one year after bariatric surgery NASH had disappeared from 85 percent of patients and reduced study pathological features after a year of monitoring the disease. NASH disappeared from a higher proportion of patients with mild NASH before surgery (94 percent) than severe NASH (70 percent). “These two studies provide a benchmark for future pharmacological intervention in NASH, across the spectrum of obesity ,” Marchesini said.
NASH with time may cirrhosis , in which the liver is permanently damaged and scarred and no longer able to function properly. With currently approved therapies available for NASH, doctors recommend that patients with NASH reduce your weight, eating a balanced diet, practice a physical activity and avoid alcohol and unnecessary medications. Read: 7 everyday things that are damaging your liver
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