A new study presented by Dr. Maciej Ostrowski Poland at the 2014 ESC Congress has found that those who treat elderly hypertensive patients with antihypertensive treatment reduces the risk of cardiovascular disease (CV), stroke and mortality.
risk of death and stroke can be reduced by antihypertensive therapy in older adults
Dr. Ostrowski, said: “Over recent decades, a number of randomized trials and meta-analyzes have supported the benefits of antihypertensive medication in reducing the incidence of cardiovascular disease (CVD) among hypertensive patients over 65 years, however, these. studies were not designed to identify the goal of adequate blood pressure (BP) in this population. ”
He added: “There is also still a great debate about the level of optimal target PA for older adults with hypertension, especially with regard to whether the reduction in systolic BP below 140 mmHg is beneficial and safe Experts have stressed that there are very limited data to make definitive recommendations. how low should reduce blood pressure in older patients, and no data on the effects of hypertensive therapy in this patient group. “? the aim of this meta-analysis was to investigate the effect of therapy of hypertension on blood pressure, and CV and mortality outcomes in patients older than 65 years. Safety? From? Decreased BP? Older adults also analyzed. The study was conducted within? Lipids and blood pressure Meta-analysis Collaboration (LBPMC) Group
The researchers analyzed data published between 1966 and 2013 in Scopus, PubMed, Web of Science, and the Cochrane Central Register of randomized controlled trials (RCTs) of appropriate studies tests. 11 RCTs were included 40,325 hypertensive elderly patients? Randomized to receive antihypertensive drugs or placebo.
They found that therapy BP lowering was associated with a significant reduction in systolic blood pressure (mmHg -12.43, 95% confidence interval [CI]: ?? -21.07 to -3.79; P = 0.005 )? And diastolic (-5.06 mm Hg, 95% CI -9.21 to -0.92; p = 0.02) ?.
It was also associated with a significant reduction in all-cause mortality by 13% (relative risk [RR] 0.87, 95% CI: 0.81 to 0.93; p <0.0001 ??), The risk of death from cardiac causes all? 18% (0.82; 95% CI: 0.73 to 0.9; p = 0.002)? cardiovascular events by 21%? (0.79, 95% CI: 0.73 to 0.87; p <0.0001), and stroke by 30% (CI: 0.70, 95% CI 0.63 to 0.77 , p <0.0001), including fatal stroke by 39% (CI: 0.61, 95% CI 0.45 to 0.83; p = 0.0015) ?. There was no significant relationship between BP lowering in older adults and the risk of hospitalization for angina (RR 1.13; 95% CI: 0.9 to 1.41; p> 0.05) O heart failure (95% CI 0.95: 0.76- 1.18 ;? p> 0.05). However an association between PA and decrease the risk of falls (1.21, 95% CI: 1.05 to 1.44; p <0.05) was observed Dr. Ostrowski said, "Antihypertensive treatment in older adults it is very effective and should be considered at all.? .. patients over 65 years old with hypertension that significantly reduces the risk of cardiovascular events, stroke and mortality All patients should be aware of the great benefits of this therapy "?? He added:?.? "There is still very limited data about possible complications associated with decreased BP in this group of patients, especially the risk of falls, that more research is therefore physicians should remember that in elderly patients therapy BP should be individualized, with BP goals tailored to individual tolerance. within the LBPMC Group are conducting a second meta-analysis to answer the question of objectives optimal BP in older adults ".
This article was originally published on medindia.net
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