How autoimmune disease affects your mood

Jun 23, 2015 | | Say something

How autoimmune disease affects your mood ;

Dr. Kimberly Sanders, ND
@_ drkimsanders

Inflammation in the brain?

A fascinating and innovative article was published this month explaining that a missing link between the immune system and brain may have been discovered. This article explains that the lymphatic vessels, which carry immune cells and inflammatory chemicals, can be found within the central nervous system (ie, brain and spinal cord). 1 lymphatics Never before have so abundantly found in the central nervous system. This discovery may have implications for patients with autoimmune inflammatory diseases, including multiple sclerosis, PANDAS, lupus, rheumatoid arthritis, and more. If there really is a physical link between the immune system found in the rest of the body and the brain, then inflammation in the rest of your body can affect what happens in your brain. Specifically, this inflammation can alter your brain chemicals products, also known as neurotransmitters, which control your mood, energy level and memory.

Flares and Feelings

Many autoimmune patients come to my clinic intuitively know that this connection is real. They know that a flare body also makes them feel irritable, tired, depressed, or fogged brain. They often say that once the outbreak subsides, the mood improves. This mind-body link can be explained by the physical connection between the brain and the immune system.

Serotonin and quinolinic acid

One way that inflammation alters your mood is by affecting serotonin pathway. Serotonin is an important brain chemical that fights depression and makes you feel happy and relaxed. Serotonin is made in the body from a precursor called tryptophan. When inflammation is high, tryptophan comes down to form an alternative quinolinic acid and kynurenic acid, instead of serotonin pathway. 2- quinoline is particularly neurotoxic and has been associated with depression. 3 quinolinic acid is elevated in response to inflammation and stimulates glutamate receptors in the brain. When glutamate, which causes excessive excitation of brain cells and ultimately cell death brain is stimulated. 3 Depressive symptoms have been shown to reduce as quinolinic acid, which leads us to seek natural inhibitors of this process is reduced.

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What can help?

An article describes a series of natural inhibitors of kynurenic acid and quinolinic acid production. Flavonoids isolated from botanicals Passiflora incarnata and Scutellaria baicalensis have demonstrated the ability to reduce levels of quinolinic acid. 4 is not surprising that both of these botanicals have been traditionally used to treat depression. Now, current research explains that these plant products can help reduce depression by reducing the conversion of tryptophan to quinolinic acid. This can reduce brain swelling and naturally restore serotonin levels.

Other interventions for reducing depression associated with inflammation, mental confusion, irritability and anxiety is to reduce inflammation in general. Patients with an autoimmune disorder have a lot of inflammation driven by tissue damage and propagated by inflammatory chemicals called cytokines. Inhibition of these inflammatory chemicals with nutrients and botanicals, such as curcumin ingredients Boswellia serrata , resveratrol and omega-3 fatty acids may reduce the conversion of tryptophan to quinolinic acid. Certainly the most important intervention that someone can do to reduce inflammation is the adoption of an anti-inflammatory diet. Today, the Mediterranean diet is one of the best researched anti-inflammatory diets. This diet is based on high intervention fruits and vegetables, whole grains, legumes, olive oil, fish, lean poultry and low consumption of dairy products and red meat to moderate. Some studies have found a correlation between the Mediterranean diet and lower levels of depression. 5 This effect could be explained by the role of the lower inflammation in altering brain chemicals.

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Who should worry about this?

Not all patients with depression, anxiety or irritability have high levels of quinolinic acid. This phenomenon seems to be more relevant for patients swell significantly, such as autoimmune patient, who is also feeling the mental confusion, anxiety, depression or irritable. It is possible that inflammation in the rest of his body is crossing her brain and causing these feelings. Balance the brain chemicals is a part of the process, but more importantly, we need to balance the immune system and reduce inflammation.

What you need to do next?

Consider measuring kynurenic acid, serotonin, or quinolinic acid to evaluate the amount of inflammation is affecting the brain. Second, continue working in reducing inflammation through an anti-inflammatory anti-inflammatory and diet supplements. Third, find the source of inflammation and reduce it.

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Kimberly Sanders Kimberly M. Sanders, ND , is a naturopathic physician licensed in Connecticut. He graduated from the University of Bridgeport and completed his residency training accredited by CNME there, too. She was named MVP 3 times ZRT Cup Competition as a medical student. Dr. Sanders has now ArthroWell naturopathic a specialty practice of rheumatology. She has undergone extensive training and pediatric rheumatology, and has lectured on the subject of autoimmunity and autism at the annual conferences CNPA and Nhand. His passion in practice is to find the underlying cause of immune dysfunction and restore balance to the immune system with functional medicine.References:

  1. Louveau A, Smirnov I Keyes TJ, et al. The structural and functional characteristics of the central nervous system vessels nodes. Nature . 2015; doi :. 10.1038 / nature14432
  2. Chen Y GJ Guillemin . via kynurenine metabolites in humans: the disease and healthy states. Res Int J tryptophan 2009; 2: 1-19 ..
  3. Bay-Richter C , Linderholm KR , Lim CK , et al. A role for inflammatory metabolites such as receptor modulators N-methyl-D-aspartate glutamate in depression and suicidal tendency. Brain Behav Immun 2015; 43 :. 110-7
  4. .

  5. Chen S, Corteling R, L Stevanato, J. Natural inhibitors Sinden indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. Biochem Biophys Res Comm and. 2012; 429 :. 117-123
  6. Sánchez-Villegas A , Martinez-Gonzalez MA , Estruch R , et al. Mediterranean diet pattern and depression: a randomized trial PREDIMED. BMC Med 2013.; 11: 208

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This article was originally published on thenatpath, Read the original article here

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Posted in: Autoimmune, glutamate, inflammation, Mediterranean diet, quinolinic acid, Sanders, serotonin

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