Neuroscientists discover how vertebrates end locomotion ;
neuroscientists from the universities of Cologne and Montreal have discovered the neural mechanisms that control the termination of locomotion. In a study published in the journal Cell Reports , which have identified the cells stop ” in the brainstem neurons and their cellular characteristics and patterns of specific activity it is characterized. The study is the result of an international long-term collaboration between the working groups of teachers and Ansgar Büschges Réjean Dubuc, who both research and neuronal activity.
In the case of vertebrates – including humans – the neurons activity in the midbrain watchdog, especially those required for locomotion. command neurons produced in this region of the brain and transferred directly to the brainstem. From there, they go through the marrow of local networks that control the activity of the muscles of the body. Although much has been known about the mechanisms of initiation and maintenance of the activity for some time in connection with the termination of the activity was only the assumption that the result of the termination of the activity of neurons in the brain stem was. Only recently it was revealed that specific neural mechanisms existed for this. Karolinska researchers discovered Stockholm Intistitutet a population of cells in mice brainstems, which makes the end of a motion sequence. The individual activities of these neurons could not, however, be described or analyzed.
In her study, Dr. Laurent Juvin and Swantje Gratsch in collaboration with Prof. Réjean Dubuc, Prof. Ansgar Büschges and colleagues were able to characterize neurons similar brain stem ( “prevent cells”) using a lamprey. To do this, MRIs, electrophysiological and kinematic methods were used to measure the activity of the cells of “stop” cells then compared with body activity. It could be shown that the “stop” cells could be activated quickly and forcefully just before the end of the movement. These patterns of activity of neurons in the brainstem were unknown until now. Interestingly, selective activation of these cells results in the termination of rapid movements, while the experimental inactivation significantly impairs this process.
These research results provide new insights into the neural control of movement termination in vertebrates, “Stop cells” are neurons in the brainstem affecting neural networks in the bone as neurons control and quickly end bodily activity.
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Posted in: Neuroscience