New relationship between diabetes and heart damage

May 16, 2016 | | Say something

New link between diabetes and heart damage

A new study has provided additional information on the impact diabetes can have on the heart, which could help to improve treatment and reduce the number of people who die from problems related to diabetes.

Complications with the heart are the leading cause of death among diabetics, but the new study has identified the specific mechanism is involved in a common form of heart damage found in people with diabetes.

Experts from the University of Texas Medical Branch, Baylor College of Medicine, University of California, San Diego and the University of Texas in Dallas found the causes of diabetic cardiomyopathy.

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The condition is a disorder of the heart muscle that can lead to heart failure and is part of the reason why people with diabetes are two to five times more likely to develop cardiovascular disease than people who are not diabetic.

Although this is a major problem, the causes of this heart disorder is not well understood, and these could be key to the development of better treatments and ways to diagnose these conditions before.

published in the journal Cell, the study focused on RNA, which provides the blueprint for the production of protein building blocks of cells. The RNA is then divided to create mRNA, which is used to build proteins. Errors with this RNA cleavage is linked to a number of diseases and can trigger the development of erroneous or harmful proteins.

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Previously, researchers had shown that levels of the protein – called RBFOX2 -. Responsible for the regulation of this RNA cleavage is much higher in the tissue of diabetic heart

In the new study, he wanted to see how RBFOX2 affected some of the defects observed in diabetic hearts and what this meant for the overall heart health and function.

The team found that RBFOX2 joins 73 percent of RNA that are mis-spliced ​​in the tissues of diabetic heart. It was found that in the way of normal processes in the heart, as programmed cell death and management of calcium, which is important for the regulation of the heartbeat.

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Dr. N. Muge Kuyumcu-Martínez, lead author and assistant professor in the department of biochemistry and molecular biology at the University of Texas Medical Branch, said the findings could help develop new tools to diagnose, prevent or treating diabetic cardiomyopathy in the future.

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