repeated failures of IVF – causes and tips to prevent common

Jun 18, 2015 | | Say something

repeated failures of IVF – causes and tips to prevent common ; IVF treatment

Motherhood is a wonderful experience, regardless of the challenges that every woman It has to happen. And this is the reason IVF (in vitro fertilization) has become a boon to most parents. However, in some cases, failures are repeated IVF. Instead of losing hope, knowing about the causes beforehand it goes a long way. Dr. Kaberi Banerjee, IVF and infertility specialist, Advance Fertility and Gynaecology Centre, New Delhi sheds light on the common causes of failures of IVF repeat and what to do about it.

Some of the most common causes of repeated IVF failures are:

Uterine abnormalities: anomalies previously undiagnosed or untreated as uterine fibroids / endometrial polyps / partition, etc., can cause implantation failure


Poor endometrium :. fine or poor quality endometrium endometrium is endometrium with poor responsiveness not be suitable for implantation

embryo quality chromosomally abnormal embryos or poor quality embryos will face implementation difficulties, and even if they can, they can not stay long. When Zone, a current embryonic layer around the oocyte, is thicker than normal, it has been associated with implantation failure due to insufficient area to rupture during fertilization.

Genetic abnormalities in gametes :. Any defects, even minor, such as chromosomal microdeletions can compromise the quality of the gamete and therefore embryos

autoimmune diseases: If you are suffering from diseases autoimmune , which could be at risk of failure recurrent IVF. Usually, detection is performed in patients with repeated pregnancy loss to rule anti phospholipid syndrome antibodies, an autoimmune disease.

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Other diseases in the mother: Thyroid disorders uncontrolled diabetes , etc., are conditions that can prevent pregnancy

the difficulty of embryo transfer a common cause of failure of IVF, the most important step remains embryo transfer. Problems during embryo transfer or blood seen in the catheter tips indicate a high probability of failure.

Suboptimal stimulation of the ovaries: This also increases the risk of failure of repeated IVF due to the inability to produce eggs for fertilization

. hidrosalpinges: hidrosalpinges, fallopian tubes dilated mainly caused due to inflammation pelici. filtered fluid into the uterine cavity, which has been found to be embryotoxic.

endometriosis :. is another disease of the reproductive system that hinders the success of IVF if not properly addressed

Age and weight – how it affects IVF

Your age and weight plays a key role in increasing the risk of repeated failure of IVF.

Age: Not all teenagers or young women always have regular cycles, ovulatory. Hence to consider a person as infertile would be wrong. Unfortunately, we still find women who have married at an early age and withstand the pressure to conceive, although its hypothalamic-pituitary-ovarian axis is not yet stable.

And women over 35 years begins to experience a drastic change in your hormone levels. This gradually causes a decrease in the number of eggs produced and also lead to irregular cycles, occasionally anovulatory. Is becoming less and more spaced apart as menopause approaches.

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Weight Do not just discard that overweight causes a high risk of failure of IVF. As women who are underweight can also expereicne repated IVF failure.

Overweight / obese Women need help with conception because they suffer mainly from SOP symptoms due to anovulation or often they have spontaneous abortions and greater possibilities of missed abortions. Hormonal changes lead to be androgen, which in turn causes poor quality eggs and therefore poor through IVF embryos.

Underweight / anorexic Women who are underweight / anorexic / athletes / those who perform strenuous exercise, often do not ovulate due to decreased hormone estrogen. This could lead to absent or irregular periods. Some may be presented as a variation of polycystic ovaries.

A step by step guide to avoid repeated IVF failures

  1. The first thing to do is a thorough examination including blood tests and ultrasound. The latter two aspects, especially help in determining ovarian reserve.
  2. Thereafter, an examination of laparoscopic hysteroscopy should do more to find and deal with physical obstacles to conception.
  3. Freshener poor quality endometrium is also done at this time. And most importantly, a sample must be sent to rule tuberculosis .
  4. hidrosalpinges can be hooked at this time to prevent the fluid embryotoxic cause failure of in vitro fertilization.
  5. After all this, the correct protocol for ovarian stimulation should be chosen and started.
  6. However, care must be taken that the endometrium is suitable for implantation – the quality and thickness. If not, then it has to be supplemented with estrogen (progynovaetc) until it becomes thick and ready for implantation and after that, in some cases.
  7. Some patients may receive granulocyte colony stimulating factor injection of either intrauterine or subcutaneously before Ovum pick up. In women with repeated IVF failure, IV immunoglobulin G when administered before embryo transfer in greatly facilitates implantation.
  8. A mock embryo transfer is extremely beneficial in ensuring smooth transfer process embryos.
  9. Following this, the patient must be supplemented with adequate amounts of progesterone and estrogen, along with baby aspirin and low molecular weight heparin to ensure positive results.
  10. If the age of the woman is tall and eggs are of poor quality, can be given the choice of good quality donor eggs.
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What can a doctor?

The doctor can help a lot in this matter by –

  • Dealing with pre-existing morbidities in women, such as thyroid disease / diabetes / metabolic syndrome X, etc.
  • Obtaining the correct body mass index to improve the chances of conception.

Once this is done, the doctor can direct you to a specialist in IVF with experience and a willingness to donor eggs and substitutes as well. This is how to choose a right FIV specailist .

Here’s a little more information

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