What is the subjective cognitive impairment? ;
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What to do when your memory is not what it used to be? Is it something serious or normal aging? It may not be Alzheimer’s disease, but it is serious enough to change your lifestyle? Learn about Subjective cognitive impairment subtle cues’ s. Knowing arrive early, effective treatment
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Recent data from several research groups have provided evidence that the decline in self-experience cognitive performance in the elderly, even those with normal performance on cognitive tests, is a risk factor for future dementia and Alzheimer’s disease, and may indicate a increased likelihood of the presence of preclinical Alzheimer’s disease. However, research on the SCD is limited by the lack of a common research framework, which prevents comparability between studies and research prevents deeper into the subject.
In response, Frank Jessen, Ph.D. University of Bonn, Germany, led an international group of researchers from Alzheimer to form the Initiative subjective cognitive impairment (SCD-I). The working group includes leading authors of the diagnostic criteria presented recently and the principal investigators of the major initiatives of biomarkers (ADNI, AIBL, DESCRIPA, Dementia Competence Network) and large cohort studies of population base. The group concluded that, “The data currently available is too limited and too heterogeneous to define SCD … as a distinct entity and highlights the need for more research on this subject.”
the initial objective of the SCD-I became then develop and disseminate a research framework for the SCD, with a focus on SCD during the preclinical phase of Alzheimer’s disease.
” this framework provides guidelines on terminology and evaluation of MSC in various research environments, “Jessen said. “It also describes the main features that increase the probability of SCD in an individual is associated with preclinical Alzheimer’s disease.”
Jessen says the new research framework “will greatly support research at the earliest stage of Alzheimer’s disease. “
the subjective perception of memory impairment in older adults was associated with post a significant decline in episodic memory – memory of specific events in the past – but not with decreased working memory and general cognitive status. The results are reported in a study by Alexander Koppara, Dipl.Psych., Of the University of Bonn, and colleagues.
Researchers studied data collected from 2,230 cognitively normal older adults with an average age of 80 years they were enrolled in the prospective, longitudinal study German AgeCoDe and evaluated every 18 months for an average of eight years. At baseline, participants were tested for memory and cognitive skills and asked, “Do you feel that your memory is becoming worse”
The 993 participants who responded “yes” were identified as subjective memory impairment (SMI). Another group of 372 who answered “yes” and also expressed concern about memory loss were classified as SMI-over-concern. At baseline, both participants SMI-over-refer to SMI and poorer performance on a test word reminder that participants do not SMI.
After eight years, the SMI group showed significant decrease episodic memory compared to non-SMI group; SMI-group-concern showed more decline even greater than in the SMI group. The differences remained after researchers adjusted for age, sex, ApoE4 status and education. There was no significant difference in overall cognitive memory or working status among the three groups.
“We show here that SMI is a predictor of the decline in episodic memory,” Koppara said. “The assessment of subjective cognitive impairment could help identify subjects for trials of prevention of dementia.”
The research framework lays the groundwork for increased research and comparable on the SCD in preclinical AD. Provides the basis for investigating the characteristics and dynamics of early symptomatic stage of AD and to assess the usefulness of SCD time as a clinical sign diagnostic biomarkers based pre-clinical Alzheimer’s.
This article was originally published on alzheimersweekly, Read the original article here