85 with dementia? Good opportunity is HS-aging and Alzheimer

Sep 28, 2015 | | Say something

85 with dementia? Good opportunity is HS-aging and Alzheimer ;

3 major dementia studies focus on HS-aging. It is a kind of almost as common as Alzheimer’s disease in the group 85 years dementia. However, few people have heard of him. Why? What makes it different?


In those who live to a very old age (beyond 85 years) HS-AGING (hippocampal sclerosis in the elderly) it is almost as prevalent as Alzheimer’s disease. Surprisingly, HS-aging seems to be a completely separate Alzheimer’s disease, although almost always Alzheimer’s disease is diagnosed while people are alive disease.

Three important documents written by Dr. Peter Nelson and others at the University of Kentucky Sanders-Brown Center on Aging, explore the neuropathology of the brain behind this poorly understood condition.

HS-AGING, like Alzheimer’s disease, the cause of dementia symptoms, such as cognitive impairment and memory disorders. Although Alzheimer’s disease is probably the most recognized cause of dementia, HS-aging also causes severe cognitive impairment in many older adults.

Overview 3 New studies on the HS-AGING:

  1. The first article, published in the Journal of Alzheimer’s Disease, is based on a very large population sample and shows that at present, around 20% of all dementia cases are diagnosed as HS-aGING at autopsy, although almost none are given a diagnosis during life. this means that the presence of this disease is currently almost unknown by health professionals who are seeing patients.
  2. A second study, “Arteriosclerosis affecting several regions of the brain” appears in a recent issue of the journal Brain , and is in the small blood vessels in patients with HS-aging and describes a specific change, called “arteriosclerosis” is present in patients with HS-aging. This small change of blood vessels may provide a novel therapeutic target to alter disease progression.
  3. Finally, the third document, “hippocampal sclerosis aging, brain disease and high morbidity prevalent,” appears in Act Neuropathologica and provides an overview of HS-aging for patients and researchers. This article reviews the relevant scientific literature and also pressed the point that HS-aging is a very common disease that exerts a strong negative impact on public health.
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It is important that doctors and scientists understand the unique pathology of HS-aging and to differentiate it from other diseases, because it is only by making an accurate diagnosis that doctors can aspire to treat people who signs of cognitive decline. These current studies represent a leap forward in the knowledge base on the HS-AGING, and represent potential new avenues to explore for the diagnosis and treatment of this serious but underappreciated brain disease.

In people over 95, a type of dementia called HS-aging is as common as Alzheimer’s disease. However, few people have heard of him. Why? What makes it different?

What is the HS-aging?

HS-aging means “Hippocampal sclerosis in aging people.”

Alzheimer’s and HS-aging are dementias. In people over 95, its prevalence is approximately equal.

HS-aging is not well known. Everyone has heard of Alzheimer’s disease. Why?

There are hundreds of types of dementia. In people aged 65 to 95, 60% of cases of dementia are Alzheimer’s disease. it is why Alzheimer’s is so well known.

At age 95, variations in balance and HS-aging becomes almost as common as Alzheimer’s.

few people have heard of HS-Aging. The main reason is because it is often misdiagnosed as Alzheimer’s disease. Why?

When dementia seen in the elderly, default diagnosis is Alzheimer’s disease. This is due to many factors, including:

  • Patients often do not want to go through extensive testing for a variety of reasons.
  • There is no simple test. Dementias differences can be subtle. Therefore, to distinguish between types of dementia is often technically challenging.
  • Cost comes into play. For example, scans of dementia F18 can run thousands of dollars. Therefore, many based on incomplete information diagnosed.
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With these realities, it is common for a diagnosis default to the most common dementia is Alzheimer’s disease.

As a result, people with dementias such as HS-Aging often live their lives thinking they have Alzheimer’s disease.

How HS-aging differ from Alzheimer’s disease?

Alzheimer HS-Aging and both damage the hippocampus. It seems that the HS-Aging hits harder than Alzheimer’s disease, causing major alterations in memory.

HS-Aging describes a brain under attack from a protein called TDP-43. This causes sclerosis, or hardening of the tissues. In the case of HS-Aging, TDP-43 proteins harden brain tissue in the hippocampus (sometimes called central memory processing), causing the loss of a large number of critical brain cells. hippocampal sclerosis is called because the hippocampus of the brain is the center of the attack.

Alzheimer’s, by contrast, is an attack on the brain plaques (made from beta-amyloid) and balls (made of tau protein). The researchers speculate that the plates are grouped and brain cells “bottlenecks” while choking tangles from within.

How HS-aging differ regular SA?

Regular hippocampal sclerosis (HS) occurs in younger people, where hardening of the brain tissue is associated with epilepsy. HS-aging is a similar hardening, but occurs in older people with different consequences. It is caused by a lifetime of physical wear and tear on the brain, similar to vascular dementia. As a matter of fact, once the 95 people affected, the combined events of HS-Aging PLUS vascular dementia really beat Alzheimer’s disease.

Why the type of material dementia?

As explained above, Biochemistry each dementia differs significantly. This involves different drugs are needed to combat the chemicals that cause dementia. A person’s response to medications and supplements will be completely different, depending on the disease.

Importantly, the F18 new imaging techniques have recently been introduced that allow doctors to see if a person with dementia has the plaques associated with Alzheimer’s disease. Using this technique helps doctors differentiate between Alzheimer’s disease and HS-Aging. This is particularly crucial in the world of clinical trials in which participants must closely match experimental drugs are being tested.

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CTE research leading to rapid improvements in treatments HS-Aging

When we talk about dementia in aging athletes, usually it is the type of dementia called CTE (chronic traumatic encephalopathy) . Recent studies showed athletes in contact sports like football are 19 times more likely than average chance of developing dementia. As a result, there has been an explosion of research on treatment of CTE.

treatment CTE has much in common with SA-aging treatment. With the new attention both of these dementias are now receiving, there are good reasons to expect new effective treatments in the immediate future.

MORE INFORMATION:
Study # 1 above was carried out in collaboration with the National Focal Point Alzheimer’s (or “NACC”, the first author of this study, Willa Brenowitz, is based in Washington state and works with NACC), allowing Nelson and his colleagues to incorporate data from dozens of federal funds Centers Alzheimer’s disease across the country. These centers are funded by the National Institute on Aging, part of the National Institutes of Health. The research was supported by the NIA grant number U01 AG016976 and AG028383 P30.

Study # 2 above was based on the analyzes that were driven through collaboration with set based on the largest NACC data. In addition, the first author, Dr. Janna Neltner, brought his fundamental experience in the digital measurement of brain pathological

Source:.
University of Kentucky Sanders-Brown Center on Aging

This article was originally published on alzheimersweekly, Read the original article here

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Posted in: Alzheimer's & Dementia, CTE, Dementia Types, Understanding Dementia

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