Memory and Amyloid

Nov 11, 2017 | | Say something

Memory and Amyloid ;

Amyloid is the prime suspect behind Alzheimer’s disease. Scientists know that hurts memory by killing brain cells. Now, new research reveals amyloid causes memory loss in brain cells perfect health, too. Learn how Alzheimer’s disease develops.


A protein in the brain is believed to be a key component in the progression of dementia can cause memory loss in healthy brains, even before physical signs degeneration appear, according to new University of Sussex research.

The study, published in the open access Nature Publishing Group Daily Scientific Reports reveals a direct relationship between the main culprit for the loss of disease Alzheimer and memory.

Alzheimer’s disease is characterized by the formation of amyloid plaques in brain tissue. These amyloid plaques are composed of an insoluble protein, “amyloid beta” ( Abeta , for short), which form small structures called “oligomers” which are important in disease progression.

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Although these proteins are known to be involved in Alzheimer’s disease, little is known about how they lead to memory loss.

researchers Sussex Neuroscience investigated how Abeta affected healthy brains of snails pond ( Lymnaea stagnalis ) by observing the effect of administration of the protein after a job training food reward .

The results showed that snails treated with Abeta had significantly deteriorated memories 24 hours later when tested with the task of food, even though his brain tissue showed no sign of damage.

lead author of the study Lenzie Ford said that this shows that Abeta alone is sufficient to lead to the symptoms of memory loss that are well known in Alzheimer’s disease.

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she said: “What we observed was that the brains of snails remained apparently healthy, even after application of the protein was no loss of brain tissue, no signs of cell death, no change. in the normal behavior of animals, and yet the memory is lost.

“This shows that the amyloid protein Alzheimer not only affect memory killing brain neurons, which appear to be specifically targeted the specific molecular pathways necessary for memories that remain. “

professor George Kemenes, neuroscientist Sussex pioneered a thorough understanding of the molecular mechanisms of learning and memory in the nervous system of pond snail, he said: “. Because we understand the ways of memory as well, the simple brain snail has provided the ideal model system that allows us to link memory loss established for pure Abeta “

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work will provide a platform for further investigation of mechanisms and effects on memory pathways that lead to this loss of memory

professor Serpell, lead author of the study and co-director of the University research dementia Sussex Group, said:. “. It is absolutely essential that we understand how Alzheimer’s disease develops in order to find specific targets for therapeutic to combat this disease “

Source:


Journal reference

  1. Lenzie Ford, Michael Crossley, Thomas Williams, Julian R. Thorpe, Louise C. Serpell and György Kemenes . effects of exposure Aß in associative long-term memory and neural mechanisms in a defined neural network Scientific Reports , 2015 DOI:. 10.1038 / srep10614

This article was originally published on alzheimersweekly, Read the original article here

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Posted in: Alzheimer's & Dementia, Understanding Dementia

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