weight loss surgery patients has recently been shown that it is associated with altered intestinal microbes. How long these changes last microbiome and if they are directly associated with weight loss are not known.
A new human study, published on August 4 in Cell Metabolism shows that two types of bariatric surgery, Roux-en-Y gastric bypass and vertical banded gastroplasty, lead to changes remodeling microbiome Similar a decade later they remain in a group of women. Microbiota transfer of bariatric surgery patients showed decreased fat mass and increase carbohydrates use in mice.
What’s more is that changes in the microbiome are specific to the surgery and not simply a reflection of altered changes weight ( BMI ), paving the way for the exploration of probiotics as an alternative to surgery to lose weight.
Bariatric – or the stomach contracts – surgery has become an effective and relatively safe option for weight loss. While the way it works is still a mystery, which can benefit obese individuals in ways that go beyond shedding pounds – for example, by improving or resolving conditions such as Type 2 diabetes and hypertension . Changes in the intestinal microbiome seem to play an important role in the metabolic benefits of bariatric surgery, but the question has been: how long?
To investigate, Fredrik Bäckhed of the University of Gothenburg in Sweden and colleagues examined gut bacteria of 14 women over 9 years after undergoing Roux-en-Y gastric bypass or vertical banded gastroplasty. Despite differences in surgery procedures, the two procedures had similar weight loss and long-term changes on the intestinal microbioma.
These effects then proved to be transferable. When the “germ-free” (which are bred to be free of all bacteria in the gut) mice were treated with stool samples of patients who underwent surgery, the animals were able to better metabolize fat through oxidation or decomposition and put in significantly less fat compared to mice colonized with feces of obese individuals.
“Our findings are important in view of the growing epidemic of obesity and associated diseases,” says Bäckhed. “Since the surgery is always a risk, it is essential to identify nonsurgical strategies. One strategy would be to devise new probiotics on the basis of our findings that can be delivered to obese individuals.”
This abstract visual representation shows how two types of bariatric surgery, Roux-en-Y gastric bypass and vertical banded gastroplasty, producing long-term intestinal microbiome changes independently BMI and that these alterations modulate host metabolism and deposition of fat mass.
Karlsson et al./Cell Tremaroli and Metabolism 2015