First uterus transplant in the United States offers hope of pregnancy for women with UFI

Feb 26, 2016 | | Say something
A team of transplant surgeons and gynecological Cleveland Clinic surgeons have performed the first transplant the nation’s uterus during surgery nine hours.
[uterus transplant]
The first woman in the US to receive Reportedly, a transplanted uterus is doing well.
Image Credit: Cleveland Clinic

The transplant is seen as an option for candidates with uterine factor infertility (UFI). UFI women may not experience pregnancy because they were either born without a uterus or uterus no longer works. It is an irreversible condition that affects 3-5% of women worldwide.

So far, the subrogation has been the only option for women with UFI, but in the US, the process is complicated legally, and in many countries is very restricted or prohibited.

A infographic created by Cleveland Clinic describes a uterus transplant that “improving life” as opposed to “save lives.”

A uterus transplant has to be accompanied by drugs to ensure that the body will not reject the foreign organ, which is designed to be a temporary measure to allow 1-2 pregnancies. After that, the anti-rejection drugs will stop and the transplanted uterus removed or allowed to disintegrate.

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uterus transplants: moving towards success

Globally, 11 transplants have taken place so far. The first was held in Saudi Arabia in 2000; Unfortunately, the uterus had to be removed after 3 months due to complications related to thrombosis.

The first successful transplant was performed in Sweden. In 2015, nine out transplants had taken place, resulting in five pregnancies and four births. Babies are born healthy and mothers risk has been minimal.

The current patient of 26 years of age, who is not being identified publicly, was reported in stable condition Thursday afternoon. The uterus transplant from a deceased organ donor.

Cleveland Clinic began the selection of candidates for uterine transplants in 2015, and the team continues to detect a total of 10 suitable candidates. All must be aged 21-39 years and have the UFI.

After selection, the first step is to stimulate a woman’s ovaries to produce eggs, which will be removed for in vitro fertilization (IVF). Ten embryos will be selected and frozen.

A uterus will be donated by a deceased donor, who must be aged 18-40 years. When one becomes available, the candidate for the surgery begin anti-rejection medications to allow your body to accept the new organ.

The transplant must take place within 6-8 hours, and blood vessels will be connected to the receiver. Menstruation will start after a few months and it will take about a year to heal the uterus.

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At this point, the embryos are thawed and implanted one by one, hopefully leading to a successful pregnancy.

During pregnancy, careful monitoring will be conducted to check hypertension preeclampsia , intrauterine growth restriction, premature rupture of membranes, premature birth and stillbirth.

The mother-to-be who continues to take anti-rejection drugs, and is likely to be through caesarean delivery.

The research team, consisting of transplant specialists, obstetricians, gynecologists , bioethicists, psychiatrists, nurses and social workers, will continue to monitor the baby for negative results. Such results could include birth defects, perinatal infections, low birth weight and income in neonatal intensive care units.

Medical News Today recently reported that cells are derived have been used to create viable sperm in mice , offering hope for the future for couples who can not have a baby because male fertility problems.

This article was originally published on MNT, Read the original article here

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Posted in: Pregnancy / Obstetrics, Women's Health

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