A new MRI technique has been developed noninvasive that can detect the early stages of Alzheimer’s disease, which could lead to better treatments for the disease.
scientists and engineers at Northwestern University have developed a magnetic resonance probe pairs a magnetic nanostructure with an antibody that seeks to brain beta amyloid toxins responsible for the onset of the disease.
These magnetic nanostructures make the accumulated toxins that appear as dark areas on MRI scans of the brain.
“We have a new brain imaging method that can detect the toxin that leads to Alzheimer’s disease,” said William Klein, who first identified the amyloid beta oligomer in 1998. He is professor of neurobiology at the Weinberg College of Arts and Sciences.
“Using MRI, we can see bound toxins neurons in the brain,” he added. “We hope to use this tool to detect this disease early and help identify drugs that can effectively eliminate the toxin and improve health.”
The new technique led to toxic beta amyloid oligomers that attack mobile synapses of neurons, memories that destroy and ultimately results in the death of neurons.
The oligomers may also appear more than a decade before amyloid plaques – which detect the current probes -. Appear
Researchers probe non-toxic delivered intranasally to mice with Alzheimer models and control animals without the disease.
In animals with Alzheimer’s disease, the presence of toxins could be clearly discerned in the hippocampus magnetic resonance imaging of the brain. No dark areas, however, were observed in the hippocampus of control group.
as well as help early detection of the disease, the survey revealed evidence suggesting that the probe MRI improves memory by binding to toxins to make them “handcuffed” and preventing them from causing further damage .
Through the demonstration of the probe, scientists established the molecular basis of the cause, detection of non-invasive imaging and treatment of Alzheimer’s RM.
repeating the experiment in the brain tissue of human who died of Alzheimer’s disease revealed large dark areas, indicating the presence of beta-amyloid oligomers.
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Posted in: Alzheimer's & Dementia