Study A study has identified a protein that is responsible for regulating the growth of blood vessels by means of the effective removal of cholesterol from cells. The study was conducted at the University of California, San Diego School of Medicine. the unregulated development of blood vessels can feed tumor growth.
Cholesterol Sets Off chaotic growth of blood vessels: Study
The work, led by Yury Miller, MD, PhD, associate professor of medicine at the University of California, San Diego professor, will be published in the advance online edition of the journal Nature May 29
Cholesterol is a structural component of the cell and is essential for normal cell function, but their excess often leads to abnormal proliferation, migration, inflammatory responses or cell death. The researchers studied how the removal of cholesterol from endothelial cells (cells lining blood vessels) impacts the development of new blood vessels, called angiogenesis process.
According to Miller, the removal of excess cholesterol from endothelial cells is essential for the overgrowth of blood vessel restriction.
“Excess cholesterol increases the abundance of lipid rafts, areas where the plasma membrane surface receptors initiate signaling events leading to angiogenesis,” Miller said. VEGFR2 is a receptor such, it plays a central role in the development of blood vessels. Research in the angiogenesis process suggests that VEGF-induced signaling in endothelial cells is important for tumor growth.
In this study, researchers show that the binding protein apoA-I (AIBP) is secreted by the surrounding tissues, and facilitates the removal of cholesterol from endothelial cells. This process interferes with the function of VEGFR2 receptor, in turn inhibiting angiogenesis.
“Studying the process in zebrafish, it was found that the time and the expression pattern AIBP is such that helps guide arteries segmental grow strictly in the dorsal direction, rather than an aberrant lateral direction,” said first author Longhou Fang, who added that future studies will explore whether AIBP or its derivatives can be used to inhibit pathological angiogenesis in tumors. Moreover, blocking the AIBP activity in the heart can, in principle, stimulate new blood vessel growth after a heart attack.
This article was originally published on medindia.net
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