The CTE dementia, unlike Alzheimer’s disease, can be diagnosed definitively

Dec 21, 2015 | | Say something

The CTE dementia, unlike Alzheimer’s disease, can be diagnosed definitively ;

Many types of dementia, such as Alzheimer’s are diagnosed clinically. That means a doctor does his best judgment of tests and interviews. New research allows CTE (Chronic Traumatic Encephalopathy) , a dementia that affects athletes, to be definitely diagnosed. Learn how doctors can know with certainty whether a patient has CTE.


For the first time, the CTE has been confirmed as a single disease that can be definitively diagnosed by neuropathological examination of brain tissue. A consensus panel of experts neuropathologists concluded that CCMA has a pathognomonic signs in the brain, a breakthrough that represents a milestone for research CTE and lays the groundwork for future studies to define the clinical symptoms, genetic risk factors and therapeutic strategies for CTE.

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criteria defining neuropathological CTE, or criteria NINDS CTE, published in the journal Acta Neuropathologica had announced earlier this year at the Foundation for the National Institutes of meeting health (NIH) board.

head hits

CTE is a progressive degenerative brain disease found in people with a history of repetitive brain trauma, including symptomatic concussions, as well as access sub- asymptomatic commotion in the head. Trauma triggers progressive degeneration of brain tissue, including accumulation of an abnormal protein called tau. These changes in the brain can begin months, years or even decades after the last brain or end of the active participation of athletics trauma. The degeneration of the brain associated with memory loss, confusion, impaired judgment, problems with impulse control, aggression, depression and eventually progressive dementia.

25 25

A consensus panel seven neuropathologists independently reviewed slides of 25 cases of various diseases associated with tau deposits in the brain, completely blinded to all clinical information, including age, sex, clinical symptoms and athletic exposure using diagnostic criteria provisional for CTE developed by Ann McKee, MD, program director of CTE at Boston University and director of Neuropathology, VA Boston Healthcare System. Neuropathologists conclude that distinguish CTE criteria other tauopathies, including aging and Alzheimer’s disease, and had a unique CTE pathological signs in the brain.

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According to McKee, neuropathologists agree on the diagnosis of CTE and confirmed the provisional rules. “The only considered specific feature for CTE was abnormal perivascular accumulation of tau in neurons, astrocytes and cellular processes in an irregular pattern in the depths of the cortical sulci,” he said McKee is corresponding author of the study. “This injury was not characteristic of any of the other disorders, including Alzheimer’s disease, tauopathy age-related or progressive supranuclear palsy, and has only been found in persons who were exposed to brain trauma, typically multiple episodes” he added.

Source:

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Reference:

  1. Ann C. McKee, Nigel J. Cairns, Dennis W. Dickson, Rebecca D. Folkerth, C. Dirk Keene, Irene Litvan, Daniel P. Perl, Thor D. Stein, Jean-Paul Vonsattel, William Stewart, Yorghos Tripodis, John F . Crary, Kevin F. Bieniek, Kristen Presas-O’Connor, Victor E. Alvarez, Wayne A. Gordon. first consensus meeting NINDS / NIBIB to define criteria for neuropathological diagnosis of chronic traumatic encephalopathy . Neuropathologica Act , 2015; DOI: 10.1007 / s00401-015-1515-z

This article was originally published on alzheimersweekly, Read the original article here

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Posted in: Alzheimer's & Dementia, CTE, Diagnosis, Understanding Dementia

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